Ans.: Our advances in therapy of COVID-19 are because of Buddha and his blessings. Therefore, Buddha is the most intimate component of all our thoughts and actions.

Ans.: A. Buddha technique of meditation allowed us to visualize medical research articles in multidimensional form, link them to relevant literature material and understand its implications in saving lives in masses. Thus, our mind is a laboratory where all research work is done to conceptualize the product for COVID-19 and how exactly it can save lives. Since all work is third party data screening, identifying patterns, and converting them to an actionable drug, in the future, we will use ‘Artificial Intelligence and Machine learning’ to save lives in masses in multiple illnesses. From a scientific point of view, our evidenced-based advances are the work of thousands of global scientists on whose work we are advancing. They will be our future research and development partners when resources and money are available. B. Conversion of Concept to Product for COVID-19: Several random extraterrestrial events guided us to advance our Technology from Concept to Product. These events are difficult to explain but are the reason that we want to write a ‘Book on COVID-19’ that will explain how extraterrestrial events shaping us to be a single person biotechnology company and contribute to the complementary targeted therapeutic vaccine of COVID-19.

Ans.: Endocrine Technology, LLC is the code name for E.T. Extraterrestrial Biotechnology Company registered in New York as LLC on February 12, 2002.

Ans.: The flash Circles on website are the circles of James Bond Movie “Dr. No”.

• Each circle is the drug development phase or stages from drug discovery to clinical applications.
• Each circle requires in excess of $100 M to advance drug from one stage to next stage.
• The chances of success are less than 0.00001 % or less than 1:10000 for example in COVID-19.
• Each circle of drug development therefore is the circle of “Valley of Death” in the drug development process.
• Note: Currently, there is no Drug Company that has a drug for COVID-19 with evidenced based scientific data that is backed with human safety record.
• Exception is Endocrine Technology, LLC
• Dr. No are the ones who don’t believe in our advances and are insensitive for the need to develop a product at the speed of illness.

Ans.: The object of the Company is to align circles of drug development expediently to develop drug for clinical applications to save lives in masses for example in COVID-19.

Ans.: ET is the code name of Buddha. He is the “ETBOND.“ ETBOND Technology is the registered trade name in USA.

Ans.: The mission of the company is to advance the vision of “Buddha” to end the cause of human suffering. Humanity, compassion and most cost effective solution to the cause of human suffering for example in COVID-19. – are the key components of our objectives.

Ans.: The cause of human suffering is “Ignorance” of human nature. Human being has failed to promptly clean up his surrounding environment in home and outside in the neighborhood. Ignoring person hygiene, disrespect for environment, global warming, rapid travel is the reason for COVID-19 spread. The Government, municipality, communities, doctors and general public in large are the victims of “Self centeredness” playing “Blame game” not realizing that it is in the best interest of nation to cooperate with each other for “Healthy Country” and economic freedom. Good health is the cheapest way to be healthy and wealthy.

Ans.: It is the technology to augment human defense against COVID-19. The trade name is registered in USA.

Ans.: Various forms of eastern and western exercises and behavioral modifications (running, weight lifting, yoga, Pranayama, diet watch) augment human defenses. Problem: Human defense is not augmented against viruses. Even the best of athletic person is susceptible to viral diseases such as COVID-19.

ETBOND TECHNOLOGY:

Concept:

1. From ancient time, human being has protected himself from environmental threats through the working of the most ancient human defense system that is medically known as “Alternate Complement System” or “Fluid Protease System in drug industry.
2. This system has educated and guided the development of ”Cellular and memory based Human Defense System“ Called as ”Delayed Human Defense System”. This system acquires memory function and able to generate antibody responses.
3. Scientists have focused on “Delayed Human Defense System” or Antibodies in “Fundamentals of Immunity” because this was easier to understand and was easier to exploit to develop vaccines and drugs for example vaccines for small pox and polio and drugs for transplants and cancer.

ETBOND Reasoning:

• Above advances are associated with high cost, adverse effects and toxicity. This is because there is “Knowledge Gap” in Fundamentals of Immunology.
• The Company initiated task to understand and fulfill this “Knowledge Gap.” It is two decade long journey and involves intense search of various literature published in the field of “Fundamentals of Immunology.”
• Our research efforts are rewarded with the discovery “Alternate Complement System” Plays a “Master Role” in human defenses not only against viruses but also against Microbes, Parasitic infections, cancer, Transplant, degenerative diseases and also in metabolic diseases such as Type 2 Diabetes. These are the subject of “Recent Advances in Immunology”
• Based on our research efforts, we have identified these advances as a potential solution to “High Cost, Adverse effects and Toxicity” in the treatment of diseases.
• Our advances are backed with approved patents in both USA and India.
• Our research efforts identified two molecular Targets.

Factor H: This is the “Hero Factor” that is immune regulatory molecule and play dominant role in fluid and cellular human defense. https://www.ncbi.nlm.nih.gov/pubmed/?term=Factor+H 3400 articles in PubMed scientific Database. Factor D: This is the Soldier of Death that has dominant role in the death of viruses, cancers by targeting flagging molecules (Arrows) and form “Membrane Attack Complex” and generating memory responses of “Delayed immunity.” Importance of these molecules in Human Defense when virus such as COVID-19 strikes. Alternate complement system gets deregulated. https://www.ncbi.nlm.nih.gov/pubmed/19707565

Ans.: We have a drug that can rebalance the “Alternate Complement System” and prevent death from COVID-19. However, to advance this drug, expedient cooperation is needed from every stack holder in life science industry and common person that is concerned about dreadful affect of COVID-19 related death and loss of productivity that directly interfere with “National GDP.”

Ans.: Artificial intelligence duplicates human intelligence with machine learning avoiding faulty behavior of humans for example in Automate car driving. Currently, USA is a leader in Artificial Intelligence. China is planning a massive investment to become a future leader. President of Russia stated ‐ “Whoever leads in artificial intelligence will rule the world”. Artificial intelligence begins with “Big Data gathering” analyzing these data to identify trends and patterns for example personalizing their shopping habits so that they can be targeted for shopping and spend money. Artificial intelligence is like arranged marriage that begins with “DATA Gathering” and targeting to get suitable marriage couples.

Ans.: India is a land full of people with ancient history that is contained in their DNA. Under some unusual circumstances, these genes get activated and allow them to excel and perform in music, art, dancing, sports, science etc. A common difference between artificial intelligence and ET intelligence is the speed with which data is processed. Artificial intelligence requires super computers to massively process data and come to conclusion through machine learning. ET intelligence, is the innate ability to process data at the speed of thought and event to execute. Thus it is like “Love at First Sight” where information is processed at lightning speed to execute actions. ETBOND Technology: Whoever is the leader in ET, will be a global leader in saving lives.

Ans.: This requires understanding the ultrafast speed with which virus causes global havoc. Watch the global spread of disease: https://multimedia.scmp.com/infographics/news/china/article/3047038/wuhan-virus/index.html?utm_source=ttd&utm_medium=display&utm_campaign=GME-I-retarget-us-scmp-ttd-uv-all_bluefin_loyal&utm_content=society_coronavirus-outbreak_3-infographic_native_0x0

Ans.: In the context of infectious diseases, a vaccine is intended for use on uninfected people in order to prevent infection in the future, by teaching the immune system how to recognize the virus and neutralize it before it can cause disease. This is known as “immunity”; the purpose of vaccines is to generate immunity against the virus and prevent people becoming infected. A vaccine will not be used on infected people. From regulatory perspective, Vaccine Includes viral particle. It has to follow ethical guidelines and drug regulatory pathway. if clinically not effective- it may lead to multibillion dollar law suits for endangering healthy subjects.

Ans.: Antiviral drug is a therapeutic drug it is for use on infected people in order to treat/cure them from the virus that is making them sick. A therapeutic drug does not generate immunity to a virus (although, it may help slow the virus down such that the body can eventually generate its own immunity) Note the fastest developer of antivirus drug is Gilead – remdesivir (https://www.gilead.com/purpose/advancing-global-health/covid-19), From a regulatory perspective, antiviral drugs follow regulatory pathway that is almost more expensive than drug pathway. It is subject to obsolescence due to viral mutation, resistance and toxicities.

Ans.: Immune adjuvant is nonspecific stimulator of innate fluid system and is used in vaccine to generate antibodies and memory responses that has time lag of 2-3 weeks to be effective. The successful company using reverse vaccinology technology to develop Factor H binding vaccine for Meningococcal infection is (Cold Spring Harb Perspect Med 2013;3:a012476, Vaccines, Reverse Vaccinology, and Bacterial Pathogenesis, Isabel Delany, Rino Rappuoli, and Kate L. Seib, Novartis Vaccines and Diagnostics, 53100 Siena, Italy. Factor H binding protein is an immune adjuvant.

Ans.:This requires in-depth understandings of A. Immune pathogenesis of Covid-19

• This involves three dimensional interactions of virus with host and its immune system.
• This is a viral survival mechanism which allows it to evade immune system and its working
• This concept is in keeping with “Recent Advances in the Fundamentals of Immunology” Covid-19 like human cell surface is highly glycosylated. Both human cell surface and viral cell surface complete or the binding with Factor H. This results in following clinical outcome.

a. Asymptomatic Carrier Stage: (When host immunity is sufficiently strong, for example in younger persons) the viral binding to Factor H may not be strong (?,25 %) this may allow virus to survive without much symptoms and allow it to remain as a carrier. This allows viral transmission to occur to sick patients in contact places ( meeting of few people) and crowded places(Public Transport system). So for the detection of Carrier stages, focus should be on younger patient screening that are more mobile and active spreader. b. Symptomatic Stage:Here immune system is weaker allowing Factor H binding to occur more (?50 % or more). Pt may have Mild to moderate symptoms due to host inflammatory symptoms. This results in overcrowding at health places such as Doctor’s office and emergency rooms or urgent care centers. Viral transmission is through contact spread examples: Sneezing, coughing and aerosol and contact area transmissions. c. Severe Cases:Here viral binding to Factor H may occur 75% or more. This contributes to severe host inflammatory responses in immune suppressed patients that has potential for high mortality from Acute Respiratory distress syndrome (ARDS) and respiratory failure. B: Complementary Vaccine:It is a small molecule that inhibit Factor H and Factor D and three dimensionally block harmful interaction of virus with host and its immune system. Complementary vaccine specifically modulates Alternate complement system and its three dimensional interactions with host and virus. Unlike vaccine (healthy people), therapeutics (Antiviral for sick people) Complementary vaccine can be used in healthy subjects, symptoms carriers, mild cases to severe cases such as suffering from Acute respiratory distress syndrome. Further it could be incorporated in vaccines and in antiviral drugs to improve therapeutic outcome and reducing the toxicity, adverse effects, mutation and resistance. Complementary vaccine concept is new and currently not available in the market. There is no separate regulatory division in Regulatory offices regulating complementary vaccines. It is in keeping with data of “Recent Advances in the fundamentals of Immunology”. This blind spot at regulatory levels and expert levels allow us to be 2-3 decade ahead of the rest biotechnology companies. Different formulation methods can be developed for strategic targeting and scaling up of manufacturing. For example 1. Prophylaxis: Nasal Formulation to Prevent binding of viral particle due to aerosol transmission in crowded places. This protects a. It self from immune detection and surveillance of immune system. b. It activate proteases by interaction with Factor D. Our drug is inhibitor of Factor H and Factor D. Therefore it works three dimensionally -to intercept harmful effects of virus with host and immune system. This strategy does not negate the conventional strategy of precaution of quarantine measures. But it gives extra layer or tool of comfort and confidence. 2. Immune Therapy of mild symptomatic carriers: Same logic as above 3. Boosting Herd Immunity: Same logic as above